The month-long festival will air on Channel 4, E4 and 4Music with Lauren Laverne hosting.
Performers such as Elton John, Kings of Leon, Justin Timberlake and Katy Perry are all set to play at the Camden Roundhouse.
Jonathan Rothery, commissioning editor for music at Channel 4, said: “We are delighted to welcome iTunes Festival back to Channel 4 for a second year.
“The lineup for 2013 proves the event’s repeated ability to attract the biggest and most varied acts in the business.”
iTunes Festival performances can also be streamed live and on demand for a limited time on iTunes and Apple devices.
Who are you looking forward to seeing?